China’s first "cell knife" surgery for 20 years: the "brave" dance on the tip of the knife

  He pioneered functional neurosurgery in China and was the "first person in cell knife" in China … … In the field of functional neurosurgery in China, Li Yongjie is a "myth". Under the dazzling aura, in essence, he will always be a scientist doctor who constantly explores new fields and a doctor who stands in the way of death and disease.

  Li Yongjie is a 79-grade college student — — After the reform and opening up, the first batch of college students changed their fate through the college entrance examination. In the early 1990s, with the tide of studying abroad, he learned "one-handed" skills in traveling to the west. Although he got the green card, he resolutely gave up the choice of returning to China. In just 20 years, he created and led a discipline to rank among the international "first phalanx" … …

  At the time of 40 years of reform and opening up, the 1.5 million-word book Functional Neurosurgery edited by Li Yongjie was published. A book, a person; A discipline, an era … …

  Open Functional Neurosurgery, walk into xuanwu hospital Institute of Functional Neurosurgery and Beijing Institute of Functional Neurosurgery of Capital Medical University, approach Li Yongjie’s team, and learn about the development of functional neurosurgery, as if seeing the dance of "brave" on the tip of a knife, and the wonderful dance skills are the never-ending steps … …

▲ Family photo of 2018 Beijing Institute of Functional Neurosurgery. Photo courtesy of respondents

▲ Family photo of 2018 Beijing Institute of Functional Neurosurgery. Photo courtesy of respondents

  Xinhua Daily Telegraph Press Conference Morality

  At the fork of Zheng Xinyi’s fate, Li Yongjie, his attending doctor and director of Beijing Institute of Functional Neurosurgery, stood there with a smile — — It was he and his team who realized the dream that "China Forrest Gump" had broken one place through surgery.

  July 12th is the 20th anniversary of the first "cell knife" operation in China. Xinhua Daily Telegraph reporter entered the organization that has become the largest number of brain pacemakers implanted in the world for 10 consecutive years — — Xuanwu hospital Institute of Functional Neurosurgery and Beijing Institute of Functional Neurosurgery of Capital Medical University.

  He was admitted to Peking University in 1979, studied abroad in 1994, and returned to China 20 years ago to establish the Beijing Institute of Functional Neurosurgery. A few years ago, he began to explore the society to run doctors and set up outpatient departments to help more people see and be optimistic about the disease … … In the recent 40 years, Li Yongjie’s fate has been closely linked with the changes of a discipline and an era.

▲ Professor Li Yongjie.

▲ Professor Li Yongjie.

  Open your eyes and see the world:

  From "the first person in cell knife" to "a seed"

  The human brain is one of the most amazing and complicated substances in the world. To move a "knife" on the brain requires not only courage, but also "real kung fu".

  The operation that Li Yongjie cured Zheng Xinyi was called "Deep Brain Stimulation Operation". Simply put, it is to put electrodes deep in the human brain. The scientific principle is that the dyskinesia of human body is caused by pathological changes in some brain cells, and their symptoms can be controlled and regulated by electrical stimulation of the pathological cells.

▲ Professor Li Yongjie performs stereotactic surgery for patients.

▲ Professor Li Yongjie performs stereotactic surgery for patients.

  Such an operation sounds simple, but in fact, human beings didn’t realize the relationship between human brain and consciousness and behavior until the end of the 19th century. The accurate treatment of brain tissue by surgery can be traced back to the emergence of stereotactic technology in 1947 — — At that time, the disease targeted by this technology was Parkinson’s disease, which was called "immortal cancer".

  At first, the patient’s hands and feet showed rhythmic tremor, slow movement, difficulty in tying shoelaces and buttons, and difficulty in putting on and taking off shoes and socks. After 5 to 15 years of illness, he gradually lost his mobility … … Parkinson’s disease is a slowly progressive disease, which mainly occurs in middle-aged and elderly people. Muhammad Ali and mathematician Chen Jingrun all suffered from this disease.

  In 1994, Li Yongjie, who had just gone abroad for postdoctoral studies, first came into contact with the cutting-edge microelectrode-guided stereotactic neurosurgery. This is a technique to stop the patient’s body tremor by destroying the "tremor cells" in the brain, which is vividly called "cell knife".

  As a neuromodulation surgery, it uses stereotactic method to locate accurately, implants stimulation electrodes in the human brain, and controls the stimulation parameters of the electrodes in the brain through the remote control device in vitro, so as to control and improve the patient’s disease symptoms. It is the most successful case for human beings to realize the dream of "brain-computer dialogue".

  "This kind of deep brain stimulator, also known as brain pacemaker, is the most advanced technical means for the treatment of functional encephalopathy in the international medical community since the beginning of the 21 ST century, among which the treatment of Parkinson’s disease patients is the most mature and common." Today, Li Yongjie still remembers the shock of that moment.

  After the patient who was treated in the operating room was accurately located in the skull, a very thin electrode went deep into her brain to find the abnormal cells, and then it was "destroyed" by radio frequency heating. Within a few seconds, the violent tremor of the patient’s right hand disappeared, and her tears welled up in her eyes: "Oh, my God, it’s stopped for 10 years … …”

▲ The Institute was established in 1998-Dr. RP-Iacono, a famous functional neurosurgeon from the United States, came to congratulate him personally.

▲ The Institute was established in 1998-Dr. RP-Iacono, a famous functional neurosurgeon from the United States, came to congratulate him personally.

  "The whole world seems to be silent, and I can only hear the voice in my heart: I must master this technology!" Li Yongjie, 57, will never forget the moment when he decided his future academic direction and even his life destiny.

  At that time, this advanced surgical technique was still a blank in China, and doctors also called Parkinson’s disease "tremor paralysis". Li Yongjie, who has been a doctor of medicine in China for several years, knows very well that there are tens of millions of patients with nervous system functional diseases like Parkinson’s disease in China, and high-level brain surgery intervention is urgently needed.

  After graduating as a postdoctoral fellow, Li Yongjie did not hesitate to join the world-renowned stereotactic neurosurgery — — The medical center of Linda University in Rome has mastered all the techniques of "cell knife" in only two years.

  "There are so many patients in China, I want to go back to China and bring back the technology I have learned!" Li Yongjie’s inner voice rang again. Comfortable life, clean environment, American green card … … Nothing can stop him from returning to China.

  "I left without hesitation." Li Yongjie said firmly.

▲ On July 12th, 1998, Li Yongjie completed the first stereotactic cell knife operation in Beijing Institute of Functional Neurosurgery.

▲ On July 12th, 1998, Li Yongjie completed the first stereotactic cell knife operation in Beijing Institute of Functional Neurosurgery.

  On July 12th, 1998, the first "cell knife" operation in China began in xuanwu hospital. Li Yongjie, who returned from school, is a surgeon, anesthesiologist, radiologist and nurse … … Because no one knows how this "sophisticated" operation is done, he needs to personally control every link.

  Heading, taking the patient to the nuclear magnetic room for brain scanning, positioning the surgical target, calculating the target position, craniotomy, drilling, inserting a very fine puncture needle to reach the target position, and inserting a microelectrode &hellip along the needle track; … Unconsciously, eight hours passed, and Li Yongjie, who was immersed in it, didn’t feel it at all. The doctors and nurses on the sidelines saw that the error of electrode positioning was less than 1 mm, and the patient’s trembling hand gradually stopped during the operation.

  "The human brain is a black box. Stereotactic technology is a bit like GPS and must be accurate to the millimeter." Li Yongjie said.

  Functional Neurosurgery Newsletter is a peer-to-peer exchange publication run by the Institute. The cover of the 10th issue published in April 2012 is a picture of Swiss national hero william tell aiming at an apple on his son’s head not far away under the oppression of colonists.

  "Through the distant time and space, we are capturing William’s breath in the picture, pulse diagnosis’s pulse, and appreciate each other’s heart is sympathetic." Li Yongjie wrote in the article "Courage and Responsibility Create Glory" on the front page of the magazine, "Because our profession is a doctor who saves lives, and the disease is ‘ Magic ’ The doctor is a bow and arrow maker. Facing the eyes of patients seeking help or even despair, facing the challenges of difficult and complicated diseases, and facing the medical risks and sociological risks brought by treatment, we are tested and challenged every day. This not only requires our confidence in our own knowledge and skills, but also challenges our courage and responsibility. "

  Neurosurgery, especially stereotactic surgery, is like shooting an apple with a bow.

  "This requires a high degree of accuracy, and no mistakes are allowed, so as to ensure that patients are safe, and ‘ Shoot ’ The disease is invisible. " Li Yongjie said.

  "It feels amazing." Lu Xiaoli, a doctor who witnessed the whole operation, remembers that after the success of the operation, more and more patients came here. By the end of 1998, Li Yongjie’s team had been able to perform dozens of "cell knife" operations every month, and a set of scientific operation standard procedures were established, and the operation time was shortened to an average of two hours.

  "I am just a seed, bringing this technology back to China and blossoming everywhere." Li Yongjie, who is known as the "first person of cell knife", said modestly that if he has made any contribution, it is to make the stereotactic technology develop more finely and safely in China.

▲ In 1999, the National Parkinson Foundation awarded Beijing Institute of Functional Neurosurgery the title of "Clinical Center of Excellence".

▲ In 1999, the National Parkinson Foundation awarded Beijing Institute of Functional Neurosurgery the title of "Clinical Center of Excellence".

  Parkinson’s disease is the most common type of dyskinesia. Epidemiological statistics show that there are 2 million patients in China, accounting for 40% of the total number of patients in the world. Due to the aging of the population, the incidence of Parkinson’s disease is still increasing, and it has become one of the common diseases in the nervous system of middle-aged and elderly people.

  In 1817, the British doctor Parkinson confirmed Parkinson’s disease in his book "On Tremor Paralysis", and then the international medical community named the disease after him.

  "This year is 201 years since Parkinson’s disease was confirmed." Li Yongjie said, "Before I went abroad, the name Parkinson’s disease had been used abroad for more than 100 years, and this disease was still called ‘ Tremor paralysis ’ . Now the country is also called Parkinson’s disease, which is the result of everyone opening their eyes to see the world. "

  The pioneering and exploration of Beijing Institute of Functional Neurosurgery has made countless patients see hope.

  As of July 12, 2018, in the past 20 years, Beijing Institute of Functional Neurosurgery has performed stereotactic surgery for 6,690 patients with dyskinesia, involving 13 types of functional neurosurgical diseases: Parkinson’s disease accounts for more than 3/4, followed by primary tremor (10.87%) and dystonia (7.17%), and other dyskinesia only accounts for 5.74%— — Include cerebral palsy, TIC disorder, Parkinson’s superposition syndrome, voluntary movement’s disease, chorea, etc.

  "At the beginning of returning to China for three or five years, we were fighting alone. In the last five or six years, hospitals and universities everywhere can’t wait to develop functional neurosurgery. " Li Yongjie said.

▲2009-9-18- Professor Ali-Rezai, an American expert on dyskinesia, visited and Professor Li Yongjie signed a book.

▲2009-9-18- Professor Ali-Rezai, an American expert on dyskinesia, visited and Professor Li Yongjie signed a book.

  The brave are invincible:

  Let functional neurosurgery blossom in China in 20 years.

  Starting from the first "cell knife" operation 20 years ago, China has established a multi-level and all-round discipline framework of functional neurosurgery, which focuses on dyskinesia, epilepsy surgery and pain, and spreads to neuromuscular spasm and psychosurgery.

  Li Yongjie’s "battlefield for one person" has also become a "team competition".

  At that time, xuanwu hospital established the Beijing Institute of Functional Neurosurgery because of his return, which is the first clinical treatment and scientific research institution in the field of functional neurosurgery in China. Since 2009, it has become the world’s largest "Deep Brain Stimulation Treatment Center", and the number of brain pacemakers implanted has been the first in the world for 10 consecutive years.

  "This is the result of a team competition, but the high technology of the brain stimulator comes from the other side of the ocean. No matter how big the implant is, it just follows, not leads." Li Yongjie is very sober. "It’s my real mission to return to China to start a business, not to be a flash in the pan, but to develop steadily."

  Faced with the huge medical demand and the blank field of functional neurosurgery in China at that time, the doctor with elegant appearance and slow speech showed the well-known word "courage" and shouldered the two burdens of talent training and discipline construction.

  It is hard to imagine that when Li Yongjie cured Zheng Xinyi’s "spastic cerebral palsy" in 2010, brain electrode implantation was still in the early clinical exploration in the world. This means that his frontier exploration will inevitably have the risk of failure.

  Li Yongjie admits that although he "cherishes feathers", he wants to be a good brain surgeon, "focusing on intelligence in the short term, ability in the medium term and responsibility in the long term". To this end, he set a rule for surgery: "I will do the most difficult, latest and risky surgery!"

▲ Professor Li Yongjie performs endoscopic surgery.

▲ Professor Li Yongjie performs endoscopic surgery.

  Once, Li Yongjie met an epileptic with a particularly complicated condition. After she failed in an operation in a foreign country, she was introduced to see a doctor by a medical elder. But after an impeccable craniotomy, her condition actually relapsed. This means that the previous judgment of the lesion is likely to be wrong.

  When Li Yongjie was called to the ward by his colleagues, what he saw was such a scene: the patient’s mother was sitting on the windowsill, desperate. Based on careful observation, Li Yongjie made a decisive second craniotomy and confirmed that the real lesion was in the parietal lobe of the brain, less than 2 cm away from the motor cortex of the brain.

  Do you want to do the third craniotomy? Who will do it? Li Yongjie did not hesitate to stand before the operating table. He carefully removed the focus cells as big as the fingernail, avoiding the dangerous motor cortex injury.

  "The patient is only 16 years old. If he is paralyzed by surgery, the young doctor may not be able to bear this huge psychological burden, then I will come." He smiled and recalled as if those thrilling "moments of life and death" were as usual.

  Dr. Lu Xiaoli, who has been following him, commented that he was "not angry and arrogant" — — "When he is around, everyone relies on him from the heart, which is the personality charm of Professor Li".

  He is honest with others.

  "If you don’t look at it, as long as I pick it up, I must be responsible for the patient to the end." Li Yongjie said, "It must be that those who dare to take responsibility make rapid progress, and those who are afraid of accidents make slow progress. In the end, it is better than taking responsibility."

  "Teacher Li often tells us that being a good doctor is the first priority. For diseases that can be cured, the treatment should be serious and accurate, and the best treatment plan should be discussed for difficult cases. For diseases that have no treatment for the time being, patients and their families should correctly understand and face the disease positively. ‘ Sometimes it’s healing, often it’s helping, always comforting ’ 。” Zhou Changshuai, a student in Li Yongjie, once quoted this sentence to describe his mentor in an article entitled "The Short Story of big doctor".

  More than 100,000 patients from all over the world were diagnosed and treated, and more than 10,000 cases were treated by surgery … … After 20 years, Li Yongjie has realized his ambition of returning to China: 16 "Xuanwu workshops" for hospitals across the country have trained a high-level "national team" of functional neurosurgery and trained thousands of doctors across the country; Cutting-edge technologies such as "cell knife", deep brain stimulation and endoscopic surgery have been introduced into China, and the number of diseases that can be diagnosed and treated has expanded to more than 30.

  "I am obsessive-compulsive disorder and perfectionist." Li Yongjie said, "Scientific research is a kind of spirit, attitude and method. To treat scientific research as work and work as scientific research, we must understand and clarify, run the spirit of scientific research through our work, and constantly expand the scope of application of technology."

  Someone asked Li Yongjie, "Aren’t you afraid to teach your disciples and starve your master?" He laughed: "I have so many new technologies and fields to learn, how can I have time to think about them?"

▲ Professor Li Yongjie is doing popular science propaganda in the column "The Road to Health".

▲ Professor Li Yongjie is doing popular science propaganda in the column "The Road to Health".

  Parkinson’s disease, primary disorder, dystonia, TIC disorder, voluntary movement’s disease, cerebral palsy, myotonia and other motor disorders, various epilepsy diseases, chronic pain such as central pain, peripheral nerve injury pain, cancer pain, visceral pain, soft tissue pain, low back pain, neck and shoulder pain, and neurospinal diseases such as lumbar disc herniation and cervical disc herniation & HELIP; … Experts from Beijing Institute of Functional Neurosurgery have treated or operated on more than 30 diseases recorded in Functional Neurosurgery.

  "In the field of functional neurosurgery, a comprehensive platform for treating diseases like ours can’t be found all over the world." Li Yongjie’s tone is gentle, but he is confident and proud. "In 20 years, I set up a platform for discipline development and brought out a team. Even if I retire, this subject will continue to develop. "

  In the conference room of the Institute of Functional Neurology, picture frames are hung on the wall in order, and each one is longer than the other — — Because this is the annual photo of the Institute.

  "Under the leadership of Director Li, our group photo lasted for 20 years. We are a big family and the team is getting bigger and bigger, so the group photos are getting longer and longer. " Lu Xiaoli said.

  Looking back on the 40 years of reform and opening-up, Li Yongjie was filled with emotion: "We have caught up with the era of reform and opening-up, which is the best and fastest period of economic, social, knowledge, science and technology development in China for thousands of years. From an ignorant teenager to a medical expert and academic leader, from an entrepreneur with dreams to the ideal landing and rooting, my growth and harvest are all thanks to the times. "

  "From an idiotic dream to a dream come true, I am more like the child running on the beautiful beach. Among the sea goods surrounded by waves on the beach, I am delighted to find several colorful shells … … Looking around, there are so many such children! "

  Ten years ago, Li Yongjie wrote this passage with emotion, which is meaningful today.

▲ In 2015, Professor Li Yongjie won the title of "Top Ten Health Guards in the Capital".

▲ In 2015, Professor Li Yongjie won the title of "Top Ten Health Guards in the Capital".

  Always on the road:

  A restless scientist

  Sharpen a sword in 20 years.

  The team of more than 100 people led by Li Yongjie has become the world-famous "China Team" in the field of functional neurosurgery, and ranks among the international "first phalanx" — — Beijing Institute of Functional Neurosurgery was awarded the title of "Clinical Center of Excellence" by international institutions as early as 1999, becoming the only clinical institution in Asia to receive this honor.

  What else does he want?

  "I am a restless person, and I naturally like to do something new and different." There was a childlike look on his face. "I hope to be recognized as a scientist doctor."

  In fact, it was Li Yongjie’s childhood dream to be a scientist, but it was accidental to study medicine.

  In 1960s, he was born in an ordinary family in Datong City, Shanxi Province. In that special time when "sports followed sports", Li Yongjie was a "silent, timid" child because of his family background of "rich peasants", and he was "aged and lonely out of proportion to his age".

  But under his seemingly "juvenile maturity" appearance, there is an interesting and curious soul hidden. He loved natural science since he was a child, and when he was 6 years old, he had a whim to make a perpetual motion machine with water currents and waterwheels. After the Tangshan earthquake, he hung a small hammer with enameled wire and passed through the ring. As long as it shook, it would trigger the ringing of the electric bell. He was very proud of this homemade "seismograph". At the age of 15, he climbed onto the roof to install an antenna, and the self-made "crystal receiver" actually received china national radio’s voice … …

  In 1977, China resumed the national college entrance examination and entered the "scientific spring" with emphasis on education and knowledge.

  "The resumption of the college entrance examination has restored the vitality of the social class." In 1979, Li Yongjie, who won the first prize in Shanxi Physics Competition, gave up the opportunity to attend the university of Shanxi Province without taking the exam and chose to take the college entrance examination, and was admitted to the top 20 in the province. His mother said, "If only our family could have a doctor, you could study medicine", which made him filial and medicine accompany him ever since.

  In 1991, Li Yongjie, who received a doctor’s degree in medicine from Shanxi Medical University and published two English papers in Brain Research magazine, saw the huge gap between domestic and foreign advanced technology. A strong thirst for knowledge made him "desperate" and sold his newly allocated house to study abroad.

  "My growth and harvest are all thanks to the times. If I don’t catch up with the golden age of 40 years of reform and opening up, I may not be able to dominate my own destiny." He said, "Therefore, I firmly believe that my seed will be the home only if it falls on the land of the motherland, and it will grow most vigorously."

  "The door of opportunity opened by reform is getting bigger and bigger, and the chances that individuals can dominate their own destiny are getting higher and higher." Li Yongjie, which chose to return to China, has indeed achieved "the most vigorous growth" — — Under his leadership, Beijing Institute of Functional Neurosurgery keeps track of the latest development of functional encephalopathy in the world, improves technical methods, improves the level of treatment and expands the scope of treatment.

▲ In 1999, Professor Li Yongjie communicated with the Swedish doctor LV-Laitinen, a pioneer of functional neurosurgery.

▲ In 1999, Professor Li Yongjie communicated with the Swedish doctor LV-Laitinen, a pioneer of functional neurosurgery.

  In March 1999, the Institute of Functional Neurosurgery successfully treated Parkinson’s disease with subthalamic nucleus destruction technology, and in the same year, deep brain stimulation technology (brain pacemaker therapy) was developed to treat Parkinson’s disease.

  In May, 1999, the first operation to treat generalized torsion spasm was successful.

  In the second half of 1999, the first operation to treat spastic torticollis, chorea and Tourette’s syndrome was successful one after another.

  In the new century, after creatively expanding the scope of surgical treatment to other dyskinesia diseases, his team began to pay attention to the work in the field of surgical treatment of epilepsy and pain … …

  "Yongjie’s team has always led the development of functional neurosurgery in China, from treating Parkinson’s disease to epilepsy to pain … …” Professor Yuxi Liu of Shanxi Medical University said.

  In the past three years, the average annual operation volume of Beijing Institute of Functional Surgery was over 1,600, and a team with their own strengths and vitality also grew up — —

  Zhang Guojun and Yu Tao focus on the localization of epileptogenic focus and microsurgical treatment of intractable epilepsy; Hu Yongsheng specializes in surgical treatment and nerve regulation of chronic pain; Zhu Hongwei is good at neurospinal and cranial neuropathy; Li Jianyu has 20 years of experience in surgical treatment of dyskinesia … …

▲ Professor Li Yongjie gave a keynote speech at the 2017 Chinese Conference on Functional Neurosurgery.

▲ Professor Li Yongjie gave a keynote speech at the 2017 Chinese Conference on Functional Neurosurgery.

  In September 2017, the Huaxia Conference on Functional Neurosurgery was held in Beijing, and more than 20 top scholars in the world and more than 100 well-known experts in China arrived as scheduled.

  In his speech at the conference, Li Yongjie introduced the summary of the world’s largest surgical cases of dyskinesia completed by the Institute in the past 20 years: a total of 6,467 cases were treated by surgery, and it was also found that the risk of Parkinson’s disease in men was 1.46 times that of women, and the overall dyskinesia was 1.45 times; At the age of onset, half of the patients with Parkinson’s disease developed before the age of 53, and half of them received surgery before the age of 61.

  In the first 10 years after returning to China, Li Yongjie devoted himself to improving the diagnosis and treatment of Parkinson’s disease and epilepsy to the international level, and then he turned his attention to the treatment of chronic pain.

  "The most common and harmful pain is disc herniation. My focus now is how to make it more meticulous and minimally invasive, in line with international concepts and models." He said.

  Exploration is always on the road — —

  "Science, solve ‘ Day ’ The problem; Technology, solve ‘ Land ’ The problem. I am still optimistic about the prospect of surgical treatment of emotional disorders such as major depression, hoping to find that key and open the door to the connection between heaven and earth. " He said.

▲ Professor Li Yongjie spoke at the 10th anniversary celebration of Beijing Institute of Functional Neurosurgery.

▲ Professor Li Yongjie spoke at the 10th anniversary celebration of Beijing Institute of Functional Neurosurgery.

  Li Yongjie, a member of the Standing Committee of the Beijing Municipal Political Consultative Conference, has repeatedly encouraged and called for the reform of the medical system. He has also done his best: in 2014, he promoted social capital to set up the Beijing Xidian Clinic, so that the advanced national specialized medical model can take root and explore a new path of graded diagnosis and treatment.

  "Medical reform has entered the deep water area, which requires not only the skills of those who bow and arrow ‘ Emboldened ’ It requires the sense of responsibility of those involved in medical reform and the courage and responsibility of reformers. The reform of the medical system is risky, and it is even more risky if the medical system is not reformed. Go on the road with responsibility, courage and responsibility, because we believe that after twists and turns and even dangers, we will eventually reap glory. " Li Yongjie’s words spoke out the common aspiration of the participants in the western clinic.

  "Every discipline has its scientific, systematic and complete requirements and development expectations … … As far as I am concerned, more than 20 years of study, research, practice and teaching experience in the field of functional neurosurgery are even more eager for it. " In 2018, Li Yongjie led the team to compile the lifelong learning and practice into a 1.5-million-word masterpiece Functional Neurosurgery. "The editorial team adheres to the concept of combining theoretical interpretation with clinical practice, and hopes to weave a whole picture in the field of functional neurosurgery with this context, hoping that it will become a classic in the field of functional neurosurgery."

  "Patients with functional diseases of the nervous system account for more than 10% of the total population, and there are tens of millions of people who need interventional therapy. The number of people who can benefit from surgery is conservatively estimated to be as high as 5 million, which is about 10 times that of patients with brain tumors. Such a huge demand for medical services cannot be ignored, and historic opportunities for discipline development should not be missed. " He appealed in the preface.

  In October 2017, Zhu Hongwei and Zhang Jiaxing of Beijing Institute of Functional Neurosurgery participated in an important international academic conference in neurosurgery, and found that this conference "no matter the lecture content or the frontier field display, the function and nerve spine account for nearly half, and everyone is working hard on stereotactic, navigation and artificial intelligence … …”

  "This conference really shows the future development direction of neurosurgery, from which we can see our shortcomings and our status. It is proud that many of the work of the Beijing Institute of Functional Neurosurgery is at the forefront of the world. I believe that in new fields, we will also keep up with the international pace and make our own characteristics in the field of neurospinal surgery. " Zhang Jiaxing said.

▲ Playing basketball is Li Yongjie's favorite sport.

▲ Playing basketball is Li Yongjie’s favorite sport.

  In the face of achievements, Li Yongjie was unusually sober.

  "We let the international advanced technology take root and bear fruit in China, and even ran away with international counterparts in clinic. Of course, there is innovation in this, but deep brain stimulation technology was invented abroad, and we still lack real original inventions. We need to open up new fields and invent new equipment, and start with creativity, research and development, market development and resource integration to establish a complete chain of scientific research and industrial development. " Li Yongjie said, "From quantitative change to qualitative change, this possibility has greatly increased now."

  Li Yongjie revealed that his team is brewing non-invasive surgery. "This is the next step in surgery and treatment, and it will be a big breakthrough. I am optimistic about it."

  On the occasion of Functional Neurosurgery in Fu Zi, it was the time when Alpha Go defeated the top human Weiqi players.

  "The brain has 60 billion to 70 billion brain cells. If you regard them as planets, then the brain is as infinite as the universe." Li Yongjie, who is optimistic about brain-computer interface, said excitedly that if we can join hands with engineers, it may connect human imagination and mobility. "That will open up a new world of functional neurosurgery".

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Before the end, let’s take a look at the interior design of Baojun Yueye Plus. Car home car owners believe that the interior colors are simple and generous, and the beige color of the interior is clean and the interior is bright. This simple design style gives people a refreshing feeling, and also facilitates the daily cleaning and maintenance of car owners. It can be seen that Bao Junyue Plus is very careful in the details, and strives to provide a comfortable and beautiful driving environment for the owners. I hope this article can help you better understand Baojun Yueye Plus and look forward to your test drive experience.

"Crowd" exposes director’s special to guide Andy Lau’s "soul pumping"


1905 movie network news On February 10, the Spring Festival inspirational comedy starring director Rao Xiaozhi was revealed to the audience for his unique absurd comedy style.

But who knew that Rao Xiaozhi, who had won 790 million box office and high reputation as a dark horse, was in a long period of anxiety after entering the "Crowd" project, and even "nervous enough to suspect that he had a heart attack".


In the face of the strongest Spring Festival, in the face of Andy Lau’s joining, Rao Xiaozhi admitted that the popularity of "Crowd" had a bad start and was worried that it would live up to Brother Hua’s expectations, but Andy Lau’s reply gave him a shot in the arm: "Your talent will definitely be seen."


Xiao Yang was tortured the worst by Rao Xiaozhi, but still praised him as a "natural director"

The studio director Andy Lau’s "soul pumping" skillfully explains the troubles of Wan Qian’s lines


As a friend of Rao Xiaozhi for many years, Xiao Yang did not hide her recognition of the director. On the set of "The Crowd", Xiao Yang was always the one who was abused the most. The director’s requirements for him were also very high, always saying "another one" "can be better", and even in a scene where Liu Dehua slapped Xiao Yang bluntly: "Brother Hua should really fan it, the effect of real fan is better."


So Xiao Yang was forcibly slapped by Liu Dehua 36 times. But when it comes to the evaluation of the director, Xiao Yang still sincerely said that "he is naturally suitable to be a director, because he is not only immersed in his own world, but also can solve the difficulties in reality tit for tat." For example, when Wan Qian was faced with a difficult line and asked for advice on the spot, Rao Xiaozhi could immediately "prescribe the right medicine" to help her understand the character’s mood.


As a director with a very strong personal style, Rao Xiaozhi has an innate sense of humor, just as Xiao Yang described it as a "high-level joy." In the filming of the scene where Andy Lau taught Xiao Yang how to play the role of being stabbed to death, the director took a flash of inspiration from Andy Lau’s traditional character characteristics and proposed, "Brother Hua, you can add that kind of twitch." As it turned out, the performance became one of the most talked-about passages because of the temporary "twitch".


Andy Lau’s original sound in Mandarin, Rao Xiaozhi incarnated as a "sparring partner"

The line "nanny style" demonstration is very professional


At the request of the director, the whole film of "Crowd" must be played by Andy Lau in Mandarin, and no dubbing is used. It is difficult to know that there are not many movies with the original sound of Hua Ge’s Mandarin, and what is even more difficult is that he has to read the tongue twister "800 Pacesetters Run to the North Slope" fluently in the film. It is said that this tongue twister scene is also the most difficult one for Hua Ge. He practices back and forth on the set and reads the script anytime and anywhere.


In this director’s special, Andy Lau broke the news that "the director will read every line specially to me." In order to have a better line effect, the director will read every line to Andy Lau first, and then the two will communicate the final expression effect. Especially for some lines of stage performances, the stage director Rao Xiaozhi will read words synchronously with Brother Hua, looking for differences, and perfecting them to the best effect over and over again.


Shouqi has been awarded the first "Online Booking Taxi Operation License" in Beijing.

Shouyue CEO Wei Dong received the "Online Booking Taxi Operation License"

  China News Service, February 8th, at 9 am today, at the Beijing Municipal Government Service Center, the capital’s first "Online Booking Taxi Business License" was issued to Shouqi.

  Beijing is an important online car-hailing market and a benchmark city for the implementation of policies in the online car-hailing industry. In order to obtain the operation qualification of the online car-hailing platform, the identification of the enterprise’s online service capability needs to go through a series of strict review processes. Shouqi Car-hailing took the lead in winning the first "Online Booking Taxi Business License" among many competing enterprises. It can be seen that it has a relatively complete online service capability, and the identification result of the online service capability can be used nationwide.

  In 2016, the Ministry of Transport and other seven departments issued the "Interim Measures for the Management of Online Car-hailing Business Services", and various localities successively issued detailed implementation rules, allowing the entire online car-hailing market to officially enter the era of "law-abiding", and also marking a new stage of orderly competition and high-end development in the online car-hailing industry.

  Shouqi Car-hailing was officially launched in September 2015. Using mobile Internet technology and the mature operation and management experience of Shouqi Group, it has continuously accelerated the transformation and upgrading of traditional industries, and has continuously accelerated in-depth cooperation with taxi companies across the country. It has built an online car-hailing platform covering 35 cities across the country, with tens of millions of users and nearly 20,000 vehicles. All vehicles operating in Beijing are Class B or above, and all drivers and vehicles are "Beijing Registered Beijing Brands", all of which meet Beijing’s entry requirements for the online car-hailing industry.

  It is reported that since the operation of the first car, it has established a "high quality, differentiation" brand positioning, to create a state guest service, to enterprise and institutional users and high-end business people as the main service direction, while pursuing corporate social responsibility, in many bad weather, Spring Festival and other car demand soaring period, do not forget the original intention, providing a more adequate social capacity protection, but also launched a series of barrier-free models and other customized warm heart services.

  Now, Shouqi has obtained Beijing’s first "Online Booking Taxi Operation License", marking the full entry of its online and offline business into the fast lane of compliance development.

  Shouqi car-hailing CEO Wei Dong said that meeting the policy access requirements is the primary condition for survival in the industry, and enterprises must rely on full competition and quality services to win customer recognition and market share if they want to develop. Shouqi car-hailing will always adhere to continuous self-innovation and technological improvement, and the next step will focus on: improving product diversification and user experience, leading the high-quality and characteristic development of online car-hailing; secondly, expanding the openness of the platform, based in Beijing, providing high-quality services to the whole country, and actively applying for license certification for landing services in relevant cities; thirdly, accelerating the integrated development with cruise cars, playing a benchmarking role, and driving the adjustment and transformation of traditional industries; fourthly, operating in good faith and lawfully, and promoting the healthy development of the online car-hailing market.

Zhiji Automobile completed the A round of equity financing, and there is still suspense in the ranking of new forces?

On August 1, Zhiji Automobile announced the completion of the signing of the A round equity financing agreement. After completing this round of financing, the post-investment valuation of Zhiji Automobile will reach nearly 30 billion yuan. This is only one year and seven months after the official establishment of Zhiji Automobile-December 25, 2020.

This round of financing was led by Bank of Communications Capital, and SAIC continued to increase investment. At the same time, it also introduced many well-known investment institutions such as ICBC Investment, National Green Development Fund, Zhiyou Venture Capital, Shanghai State-owned State-owned Enterprise Comprehensive Reform Fund and CITIC Securities Investment.

The first model of Zhiji Automobile, Zhiji L7, was delivered on June 18th. As of July 31st, this model has delivered 1,051 vehicles to users, making it the fastest model with cumulative delivery of more than 350,000 yuan of luxury pure electric vehicles in China.

After the completion of the A round of financing, the development of Zhiji Automobile is bound to further accelerate.

According to the plan, in the second half of this year, Zhiji will also go on the market and deliver the L7 SUV model Zhiji LS7. By then, Zhiji will form a "double flagship" product structure. In 2023, Zhiji will also introduce two pure electric intelligent luxury B-class models.

After the first shot was fired by Zhiji L7, can Zhiji Automobile pursue victory and reshape the current new power pattern?

On November 26, 2021, SAIC announced that it would jointly invest with Zhangjiang Hi-Tech and Alibaba to set up Zhiji Automobile, a high-end intelligent pure electric vehicle project. This "No.1 Project", which was previously code-named "L" in SAIC, officially surfaced, and Zhiji Automobile also entered the running state.

Less than two months later, on January 13, 2021, two "mass production vehicles" of Zhiji Automobile were released in Shanghai, one was the pure electric car Zhiji L7 and the other was the pure electric SUV Zhiji LS7.

Zhiji L7 is the first product introduced to the market by Zhiji Automobile. Since the nationwide user delivery was started on June 18th, the first delivery volume of Zhiji L7 has exceeded 1,000 vehicles. This allows Zhiji Automobile to quickly enter the public’s field of vision from a young brand that has just been born.

In today’s new energy vehicle market, new products are listed together. As far as high-end models are concerned, a number of models have been listed this year, including Weilai ES7, Tucki G9 and Ideal L9, and the delivery time is within this year. In this "Wei Xiaoli" high-end product fight in 2022, why can Zhiji L7 stand out?

First of all, the products of Zhiji L7 must be excellent.

The electrification level of a new energy vehicle is the embodiment of its basic skills. In this respect, Zhiji L7 has the ability comparable to that of a million luxury cars. Zhiji L7 adopts four-wheel steering all-wheel drive system and front and rear mixed tire width design, especially the latter’s four-wheel drive system with mixed tire width and partial rear drive characteristics. Due to technical barriers and high cost, this kind of technology is rarely used in practice. At present, only Porsche Taycan applies the same design in electric vehicles.

In terms of assisted driving, the descriptions of various new energy brands on the market are dazzling, but some technologies are often not mature, resulting in uneven actual experience, and Zhiji Automobile hopes to create a "more human-like" intelligent driving experience.

At present, Zhiji L7 can cope with the high-order ability of complex road scenes such as "traffic jam on congested roads", "big cars dodging with special-shaped cars" and "big curvature curves" only through visual fusion scheme. This is due to the artificial intelligence super algorithm empowered by Zhiji L4-level same algorithm platform.

With the increasing intelligence level of new energy vehicles, software OTA has become a standard. However, Zhiji Automobile does not equate simplicity with intelligence, but insists on the technical route of coordinated upgrade of software and hardware, and regards Zhiji Automobile as a growing "digital life".

In other words, with "upgradeable hardware" as the growth trunk, "software iteration" as the development thinking, and iteration on the cloud driven by numbers, the "smart car" has the ability of self-evolution.

Different from fuel vehicles, the attributes of smart cars have changed now. It is no longer just a means of transportation, but a mobile space, which meets more diverse needs for travel, work and entertainment than in the past.

This also means that users put forward higher requirements for the comfort of cars, and in all these comfortableness, although the air health level is extremely important, especially for the mother and baby groups, it is often overlooked.

The 180+ clean and high-definition cockpit is a major feature that distinguishes Zhiji automobile from other brands. Through the whole industrial chain control far exceeding the national standard benchmark, Zhiji has realized the industry’s first pure taste workshop, and the new car will have a healthy air level after being placed for 180 days. This also allowed Zhiji to get the perfect score of CN95 fresh air cockpit certification, the only one in the industry.

Due to these characteristics, Zhiji Automobile has won the recognition of a large number of users from an emerging young brand in a very short time, and competed with Tesla, Weilai and Ideality in the high-end market.

Nowadays, with the completion of A round of equity financing by Zhiji Automobile, the future of Zhiji Automobile’s rapid development is very clear.

As a new car-making force that landed in the capital market earlier among the new forces, "Wei Xiaoli" has become a solid head of the new energy track. These three companies were established around 2014 and 2105, and many models are currently on sale. Last year, the delivery volume was close to 100,000.

Behind "Wei Xiaoli", there are Nezha and Zero Run, whose delivery volume has increased rapidly since last year. With their cost-effective products, they have gained a firm foothold in the second echelon.

From the establishment of the company to the launch of products, although the speed of Zhiji has been very fast, it is not too early to enter the game.

Under such circumstances, it seems that it is not easy for Zhiji Automobile to break through. In addition to the most important product strength, it is particularly important whether Zhiji has the advantage to widen the gap with its competitors in terms of system, service and even resources.

Different from the "Wei Xiaoli" Internet cross-border car building, Zhizhi has its own unique advantages in the background of car building.

On the one hand, Zhiji is backed by SAIC, the largest automobile group in China, and can share SAIC’s rich experience in automobile manufacturing, ensure product quality and shorten the cycle of making cars. This is also the reason why Baidu built a car and bound Geely early.

On the other hand, Alibaba and Zhangjiang Hi-Tech provide support for Zhiji’s software and intelligence. As the largest artificial intelligence company in China, Alibaba will empower Zhiji Automobile in terms of cloud capability, data security, intelligence and future cutting-edge technologies. Zhangjiang Hi-tech Park, known as "China Silicon Valley", provides technical soil for the growth of Zhiji automobile.

In the first half of this year, due to uncertain factors such as epidemic situation and local conflicts, the automobile supply chain suffered an unprecedented impact. Stopping production and reducing production are the common difficulties experienced by most manufacturers, which once challenged the lean production mode of the automobile industry. The ability to control the supply chain has also become one of the core competencies of current automobile companies.

At present, Zhiji has established in-depth cooperation with Contemporary Amperex Technology Co., Limited, Momenta, Zebra Zhixing, Huayu Vision, Yanfeng Group and other leading enterprises in the automobile industry chain. In the future, this will bring more gains to Zhiji’s spare parts supply and cost.

If Zhiji’s strong background gives it a higher starting point, then the "Yuanshigu User Data Rights Plan" is entirely from Zhiji’s own innovation ability.

Through the "Original Stone Valley User Data Rights Plan", Zhiji applied the blockchain technology to the smart car industry for the first time, with 300 million "original stones" corresponding to the growth rights of Zhiji’s founding value, and gave back the contribution of user data in the form of data rights.

This means that Zhiji makes cars no longer "consumables" in the traditional sense, but can constantly "add value" through the use of users, bringing them a steady stream of new value.

For example, new users can use up to 6,800 rough stones and 10,000 yuan in cash to exchange for the laser radar integrated intelligent driving hardware system. According to Zhiji’s plan, in the future, the original stone can also be used to exchange software and hardware upgrades, enjoy services, limit fine products, digital collections and limit experience activities.

This is the first in the world. On July 12, 2022, Zhiji Automobile specifically announced the details of the rights and interests of the original stone convertibility, and penetrated the mining path of the original stone, and this user data rights plan officially landed.

Following Zhiji L7, the SUV model Zhiji LS7 will also be listed and delivered in the second half of this year, and two pure electric smart luxury B-class models will be introduced next year. These products will quickly enrich Zhiji’s product matrix, so as to bring greater brand effect.

A young brand, how to tear open the existing pattern to find a place? Zhiji Automobile will give an answer.

Degang Guo countered Cao Yunjin: I will take care of you if others are at the end of their rope in the future.

  Hualong. com at 8: 10 on September 25th (Chief reporter Huang Jun) After 20 days in Cao Yunjin, Degang Guo finally wrote a post in Weibo to respond to the grievances between the master and the apprentice. Many people think that Degang Guo is fighting back, only to find that he left a meaningful sentence at the end of the article — — "In the future, if there is a horse riding high and running short, and there is no one to solve the problem, I don’t care, I care about you."

  Why didn’t Degang Guo respond before? Degang Guo said, in terms of Cao Yunjin’s cultural level, it is not easy to write down these 6,000 words slowly, even if you read them. Trying to figure out the scene at that time was about one person’s dictation, everyone’s help, someone’s input, and collective polishing. "I have to respond to every composition. If I come to this novel, I will be exhausted."

  Degang Guo believes that this incident is also regarded as cyber violence, and now cyber violence has reached its peak. "A group of people to scold and scold, there is no bottom line. Good or bad, true or false is not important to them. The key has another point to vent, which is really happy. People need to vent in an environment without consequences, which shows how unsatisfactory life is. These outstanding talents, listening to the wind is rain, really think that they are caught, biting their mouths and shaking their heads. "

  This time, Degang Guo refuted and responded to Cao Yunjin’s earlier long articles one by one. For example, he thinks that teaching cross talk is different for each apprentice. Because everyone’s understanding and expression are different. "I taught He Wei" Spitting Lotus "not to let Xiaojin attend, and I didn’t let others listen when I taught Xiaojin. This is a teaching method, not an experience of oppression. "

  Degang Guo also praised Xiaojin for his cleverness and cross talk, and sincerely hoped that he would become popular. Create opportunities to praise him, take him to do programs, and give him a special cross talk, which is slowly becoming popular.

  "People’s ambitions are constantly expanding with the change of position, and no one is no exception. One of Xiaojin’s favorite words after drinking is: I support half of Deyun Society! I don’t know where to start with this sentence until today. For a time, the younger brothers didn’t even dare to talk to him in the background. When they met opposite, they had to stop and bow respectfully to greet him. The expression of greeting was not good, and they had to be carried to him again. Whoever doesn’t praise him and treat him as a god will be scolded and threatened. During the second enrollment of Crane Word Department, the teachers held a meeting on the second floor, but they didn’t agree. Xiaojinju punched Mr. Xie Tianshun. Mr. Xie is a cross talk treasure, and he is the same generation as Mr. Hou Baolin. Three generations older than Xiaojin, he should call bodhi old zu. But he regarded his seniority as dirt and dared to fight against his ancestors. Later, Xiaojin met an investor who was said to be rich. In my impression, this investor can be close to the people. He can eat two boxes of lunch in the background and watch the fragrance. This gentleman was later sued for slandering a movie star, which shows that his work is very busy. Anyway, after Xiaojin knew this bento tycoon, he became even more unscrupulous and felt that he had a backer. At this time, his face became more and more ugly … …” Degang Guo pointed out that since 2009, Xiaojin has basically stopped performing in a small theater. He went outside to take pictures and do private work, and he earned money by himself.

  Later, Degang Guo also described in detail the whole story of their war.

  "All this until January 18, 2010, my birthday, finally had an outbreak. In Guo Jiacai, Sanlitun, all the people of Deyun Society gathered together. Xiaojin shouted at everyone with wine and madness. And shouted: I quit! Zhang Deyan, the daughter of Mr. Zhang Wenshun, begged Xiaojin to come back and said, Please look at my father’s face! Xiaojin shouted: I don’t fucking look at anyone! Turning and walking to the door, I knelt in front of the statue of Guan Gong in the front hall and said loudly, Master Guan is my witness. If I go back to Deyun Society, I will be a * *. After swearing, she turned and left. Zhang Deyan chased her to the road and stopped her. Xiaojin pushed her to the ground and drove away. Of course, there is another reason behind why it was so noisy that day. That’s why Yunzike wanted to expel two people … …”